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RNA-binding protein and tumor biotherapy: new opportunities and strategies
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Abstract:
RNA-binding protein (RBP), due to its unique biological functions, has become one of the favorite screening targets for tumor biotherapy, which is likely to bring new opportunities for tumor biotherapy. RBP can regulate the DNA-RNA-protein interaction network in tumor cells, tumor microenvironment immune cells and interstitial cells, and thus widely affecting tumor occurrence and development, anti-tumor immune response and tumor immune evasion. Nowadays, the research of RBP-related tumor biotherapy mainly focuses on therapeutic vaccines, immune cell therapy and epigenetic modulation therapy etc., and some of the research advances have been applied into the clinical trial. With the development of new theories and technologies and the innovation of research models,RBP-targeted therapy has been gradually getting rid of the dilemma of difficult target and poor efficacy, and ushering in new opportunities. New strategies such as improving precise targeting and optimizing drug combinations have injected new vitality into tumor biotherapy, which is of great significance to the development of personalized medicine.
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