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Platelets: an emerging target for the diagnosis and therapy of cancer
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Abstract:
Platelets are considered as important participants in the process of tumorigenesis and tumor development, which can directly or indirectly affect the growth and metastasis of tumors by constructing an inflammatory microenvironment, promoting angiogenesis and mediating tumor immune escape. As the tumor microenvironment dynamically changes, the number, volume, and molomics of platelets change accordingly, suggesting that platelet-related biomarkers have great potential to reflect tumor load evolution. Based on the promoting effect of platelets on the process of tumorigenesis and tumor development, platelets are considered as important targets for tumor biotherapy. Targeted inhibition of platelet function can significantly control tumor progression and improve patient outcomes. In addition, platelets have a strong affinity for tumor tissues. Constructing targeted anti-tumor agents with the idea of platelet-targeting or platelet-mimicking can effectively increase the affinity towards tumor tissues and the biocompatibility of nanodrugs, which is an emerging strategy to improve the efficiency of targeted therapy. This paper focuses on the complex interactions between platelets and tumors, summarizing the mechanisms of action and highlighting platelet-related tumor markers and anti-tumor targeted therapies.
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