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Archive > Volume 30 Issue 2 > 2023,30(2):108-113. DOI:10.3872/j.issn.1007-385X.2023.02.002 Prev Next
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Renewed understanding of nicotinic acid and its derivatives: from traditional nutrients to cancer prevention and treatment
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Abstract:
Nicotinic acid belongs to B vitamins and is one of the essential vitamins for humans. In the past, the main cognition of nicotinic acid remained on its nutritional functions, such as participating in the maintenance of neural function, the promotion of metabolism and development, and the protection of cardio cerebral vessels. With the development of researches, in recent years, multiple studies have shown that nicotinic acid and its derivatives play key roles in the prevention and treatment of cancer. Nicotinic acid and its derivatives could affect the biological functions of tumor cells, participate in immune regulation, promote the antitumor efficacy of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors, and maintain the genomic stability through a variety of molecular pathways in a poly ADP-ribose polymerase (PARP)-dependent manner. This review summarizes the research approaches and the latest progress in the studies of the role nicotinic acid and its derivatives play in cancer prevention and treatment and assess the prospects of its further research and application direction, with the hope of helping promote the application of nicotinic acid and its derivatives in comprehensive cancer prevention and treatment.
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