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Archive > Volume 30 Issue 4 > 2023,30(4):275-285. DOI:10.3872/j.issn.1007-385X.2023.04.001 Prev Next
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Genome editing in cancer biotherapy: strategies, challenges and future directions
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Abstract:
CRISPR gene editing technologies have had a revolutionary impact on many disciplines and fields, and have also greatly changed research methods of tumor biotherapy and promoted the formation of new therapeutic strategies. In tumor researches, gene editing accelerated the discovery of potential targets in biotherapeutic tumor cells and immune cells, promoted new editing strategies of "tumor cell normalization" therapy through targeting oncogene，tumor suppressor gene, epigenetic molecular, drug resistance gene etc. It also promoted the iteration of adoptive cellular therapies of CAR-T/TCR-T cells to "universal" and "off-the-shelf" therapies, and greatly accelerated the clinical application of cell therapies such as that of CAR-T cells. With the development of more accurate gene editing systems, the continuous progress of gene delivery strategies, the development of multi-target editing, site-specific insertion and in vivo spatio-temporal editing, the off-target effect of gene editing can be further reduced, the safety and accessibility improved and the cost controlled. In the future, gene editing will be more widely used in tumor biotherapy, and is expected to achieve new breakthroughs in the treatment of solid tumors.
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