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Archive > Volume 30 Issue 8 > 2023,30(8):649-655. DOI:10.3872/j.issn.1007-385X.2023.08.001 Prev Next
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A new approach to tumor immunobiological therapy：tumor vesicles
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Abstract:
Mammalian normal cells and tumor cells can release extracellular vesicles with 0.1-1 μm diameter when apoptosis or signal stimulation occurs. These signals stimulate the cytoskeleton changes to cause the plasma membrane to wrap the cellular contents and form extracellular vesicles, which are called tumor vesicles, which not only affect the biological characteristics of tumor cells but also have a profound impact on the tumor immune microenvironment. In addition to the biological effects, tumor vesicles can be used as a natural drug carrier, delivering therapeutic drugs to tumor cells and exerting anti-tumor effects. Follow-up studies have confirmed that drug-delivery tumor vesicles have a good anti-tumor activation effect in both innate and acquired immune responses. At present, drug-delivery tumor vesicles have entered the stage of clinical application. It has shown good application prospects in treating cholangiocarcinoma and malignant pleural effusion.
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