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Archive > Volume 30 Issue 9 > 2023,30(9):804-809. DOI:10.3872/j.issn.1007-385X.2023.09.009 Prev Next
Clinical Research
Interaction between BCSG1 and Hsa-circ-0026352 in genetic susceptibility to invasive breast cancer
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Abstract:
Objective: To investigate the interaction between breast cancer specific gene 1 (BCSG1) and Hsa-circ-0026352 in genetic susceptibility of invasive breast cancer (IBC). Methods: 100 IBC patients admitted to Wuhan Hospital of Integrated Traditional Chinese and Western Medicine between June 2019 and May 2022 were selected as the study subjects, and the expression of BCSG1 in IBC tissues and their corresponding paracancerous tissues was detected by immunohistochemistry. The study subjects were classified into negative group, weakly positive group, and strongly positive group according to their protein expression level of BCSG1 in IBC tissues. The clinicopathological characteristics and expression of estrogen receptor (ER), progesterone receptor (PR), epidermal growth factor receptor-2 (HER-2) and Hsa-circ-0026352 of the patients in three groups were counted, and the trends and interactions of BCSG1 expression with the above parameters were analyzed using Logistic regression equations and maximum likelihood method. Results: The protein expression of BCSG1 was significantly higher in IBC tissues compared with the paracancerous tissues (P<0.05). Strong positive BCSG1 protein expression was associated with lymph node metastasis, differentiation degree, clinical stage, HER2 expression, and Hsa-circ-0026352 expression (all P<0.05). There was an interaction between strong positive BCSG1 expression and IBC (P<0.05). The interaction between BCSG1 expression and IBC was most significant in patients with positive Hsa-circ-0026352 expression (P<0.001). The interaction between BCSG1 expression and IBC was most significant in patients with clinical stage Ⅲ and low differentiation (all P<0.001). Conclusion: BCSG1 is closely related to IBC and interacts with Hsa-circ-0026352, clinical stage and degree of differentiation, which can collectively increase the risk of IBC.
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