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Archive > Volume 30 Issue 10 > 2023,30(10):855-861. DOI:10.3872/j.issn.1007-385X.2023.10.001 Prev Next
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Stem cell-like CD8+ T cells: a new pioneer in cancer immunotherapy
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Abstract:
CD8+ T cells are the major players in anti-tumor immune responses. Immune therapies have made significant breakthroughs in the field of cancer treatment by reshaping the ability of CD8+ T cells to kill tumor cells. But clinical benefits have been limited to some patients and certain cancer types. The key to improving cancer immunotherapy depends on how to overcome the CD8+ T cell dysfunctions. In recent years, quite a few researches have revealed the stemness regulation mechanisms of CD8+ T cells,discovered that stem-like CD8+ T cells possess self-renewal and proliferation abilities and stated the importance of this cell subgroup in maintaining sustained cancer immunotherapy responses. In this paper, we will review the molecular and functional characteristics of stem-cell like CD8+ T cells, and the intrinsic and extrinsic influencing factors of CD8+ T cell stemness, summarize the present stemness reprogramming strategies targeting CD8+ T cells, and further look into the ideas and methods of improving the therapeutic efficacy of cancer immunotherapy through targeting CD8+ T cells stemness programs.
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