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Archive > Volume 30 Issue 10 > 2023,30(10):908-913. DOI:10.3872/j.issn.1007-385X.2023.10.009 Prev Next
Clinical Research
Analysis of leukocyte and neutrophil changes before and after immune-related adverse events in patients treated with anti-PD-1 antibodies
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Abstract:
Objective: To provide a new basis for the differential diagnosis of immune-related adverse events (irAEs) and infectious inflammation by comparing the changes of the main indicators in blood routine examination before and after the occurrence of irAEs.Methods: The clinical data of 201 patients with malignant tumors who had irAEs after receiving anti-PD-1 antibody therapy in Henan Cancer Hospital between August 2018 and June 2022 were retrospectively analyzed. The main indicators of blood routine examination before anti-PD-1 antibody treatment, before and after irAEs were collected. The statistical differences of blood routine index values before and after treatment were analyzed by paired t-test. Chi-square test was used to analyze the statistical difference in the positive rate (the proportion of blood routine index values above normal) before and after treatment. Results: 258 irAEs were observed in the 201 patients, of which 27 (13.4%) developed 2 or more types of irAEs, and 214 (82.94%) irAEs did not cause fever; The white blood cell count (t=1.087, P=0.278), neutrophil count (t=0.959, P=0.338) and neutrophil percentage (t=0.817, P=0.414) did not increase significantly after irAEs compared with those before anti-PD-1 antibody treatment. The numbers of cases above the normal value were 28 vs 38 (χ2=1.737, P=0.187), 32 vs 44 (χ2=2.222, P=0.136), 45 vs 55 (χ2=1.240, P=0.265), and the differences were not statistically significant. Conclusion: After the occurrence of irAEs, there were no significant changes in peripheral blood white blood cell count, neutrophil count and neutrophil percentage, which may be of reference significance for the differential diagnosis of infectious inflammation.
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