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Archive > Volume 30 Issue 12 > 2023,30(12):1035-1042. DOI:10.3872/j.issn.1007-385X.2023.12.001 Prev Next
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The role of RNA m7G modification in tumorigenesis and tumor development
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Abstract:
N7-methylguanosine (m7G) is one of the most common RNA modifications in epigenetic regulation, it plays an important role in the processing and metabolism of a variety of RNA molecules such as messenger RNAs (mRNAs), ribosomal RNAs (rRNAs), transfer RNAs (tRNAs) and microRNAs, and thus participates in many cellular processes such as cell proliferation, differentiation, apoptosis and migration. Increasing evidence suggests that m7G methylation is involved in tumorigenesis and tumor development. The abnormal m7G methylation is closely related to tumor development and progression by regulating the expression of multiple oncogenes and tumor suppressor genes, to promote or inhibit, the progression of various types of tumors. Molecules modified by m7G methylation and their regulators can be potential targets for tumor diagnosis and therapy. In this article, the recent advances in m7G modifications, the detection methods of m7G modification and the potential molecular mechanisms of the role of m7G modification in tumorigenesis and tumor development cancer are reviewed.
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