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Archive > Volume 31 Issue 2 > 2024,31(2):113-120. DOI:10.3872/j.issn.1007-385X.2024.02.001 Prev Next
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Leukemia inhibitory factors： the critical role in tumor development and implications for targeted therapy strategies
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Abstract:
Leukemia inhibitory factor （LIF） is a pleiotropic cytokine of the interleukin-6 （IL-6） family, which was first identified as being able to inhibit the proliferation of mouse myeloid M1 leukemia cells and induce their terminal differentiation. LIF is widely involved in the regeneration of organs, neural development, and immune regulation, and also plays an important role in the development of tumors. In contrast to its inhibitory effect on the proliferation of leukemia cells, LIF typically facilitates the progression of many solid tumors. Elevated expression of LIF has been observed to contribute to the development, metastasis, treatment resistance, and evasion of immune response in tumors, hence correlating with a poor prognosis in patients. Focusing on the functions of LIF physiology and pathology and the holistic nature of the signaling pathways it regulates and searching for new targeted drugs is important for the development of targeted therapeutic strategies for the LIF pathway.
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