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Archive > Volume 31 Issue 4 > 2024,31(4):319-325. DOI:10.3872/j.issn.1007-385X.2024.04.001 Prev Next
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The role of RNA m7G modification in tumorigenesis and tumor development
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Abstract:
In malignant tumor tissues, tumor-associated neutrophils (TANs) have become a crucial component of the tumor microenvironment. The role of TANs in tumors is multifaceted. On one hand, TANs can directly kill tumor cells or mediate the collaborative anti-tumor activities of other immune cells. On the other hand, TANs can promote tumor angiogenesis, extracellular matrix remodeling,and tumor cell immune evasion. The heterogeneity of these functions of TAN is formed under regulation by various mechanisms within the tumor microenvironment and plays an important role in tumor development or suppression, thus making it crucial to investigate the mechanisms underlying TAN heterogeneity and functional transitions in tumors and their potential clinical significance. These investigations not only help develop suppressive drugs and therapies targeting pro-tumor neutrophil subpopulations, but also further promote the establishment and screening of new evaluation standards for more immunotherapy beneficiary population groups.
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