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Archive > Volume 31 Issue 5 > 2024,31(5):429-436. DOI:10.3872/j.issn.1007-385X.2024.05.001 Prev Next
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Innate lymphoid cells and cancer immunoediting
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Abstract:
The genesis and progression of cancer is a process of immunoediting that consists of 3 phases, namely elimination,equilibrium and escape phases. This process is also a microevolutionary game process between the body and the tumor. Data from mouse tumors and some human tumors shows that both T cell-based adaptive immunity and innate lymphoid cell (ILC)-based innate immunity participate in cancer immunoediting. The ILCs, which belong to tissue-resident cells and consist of multiple subsets, are a unique branch of the innate immune system discovered over a decade ago. The characteristics and functions of ILCs exhibit significant heterogeneity and are regulated by a variety of factors secreted by various kinds of cells. ILCs participate not only in the regulation of tissue homeostasis and inflammatory responses, but also, through various mechanisms, in the formation of tumor microenvironment and cancer immunoediting process. This paper studies the classification and characteristics of ILCs and their roles and mechanisms in tumors, aiming to explore new thoughts for the pathogenesis, diagnosis and treatment of tumors.
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