Mobile website
Archive > Volume 31 Issue 6 > 2024,31(6):541-551. DOI:10.3872/j.issn.1007-385X.2024.06.001 Prev Next
Expert Forum
A new perspective on tumor immunotherapy: the role and significance of RUNX
- Article
- Figures
- Metrics
- Preview PDF
- Reference
- Related
- Cited by
- Materials
Abstract:
RUNX, a member of transcription factor family, plays an important role in the regulation of mammalian cell proliferation, differentiation, lineage development, osteogenesis and neurogenesis. The studies of RUNX have revealed the diversity of its function and its role in tumor genesis and progression. RUNX family members have different functional manifestations in different types of tumors and have different levels of association with various components in the tumor microenvironment. RUNX family members regulate the lineage development and differentiation of CD4+ helper T (Th) cells and CD8+ cytotoxic T lymphocytes (CTLs) in the tumor microenvironment, modulate the phenotype, differentiation, and survival of tissue-resident T-lymphocytes, and drive the proliferation activation and tissue-resident of NK-cells. RUNX family deletion leads to MDSC proliferation and maturation activation, which induces a tumor immunosuppressive icroenvironment. The expression of RUNX family members also significantly correlates with the degree of infiltration of tumor-associated fibroblasts (CAFs) in the tumor microenvironment, the infiltration of different immune cells, immune checkpoint gene expression, and drug sensitivity, which could serve as potential prognostic markers of tumors and as targets for tumor immunotherapy, and the combination with CAR-T cell therapy has great potential for application. This review focuses on the basic structure and function of RUNX and its role in the regulation of various components in tumor immunity and microenvironment, aiming to provide a new perspective for tumor immunotherapy with RUNX as the main target in the future.
Keywords:
Project Supported:
Clc Number:
