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Archive > Volume 31 Issue 9 > 2024,31(9):888-894. DOI:10.3872/j.issn.1007-385X.2024.09.007 Prev Next
Clinical Research
The expression and clinicopathological significance of structural maintenance of chromosome 4 in breast cancer
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Abstract:
Objective: To investigate the expression of structural maintenance of chromosome 4 (SMC4) in breast cancer and its prognostic value. Methods: The expression of SMC4 gene in breast cancer tissues and its correlation with the clinicopathological characteristics of patients were analyzed using the TIMER, GEPIA, UALCAN and GEO databases. The expression of SMC4 protein in breast cancer and adjacent normal tissues was detected using immunohistochemical (IHC) staining. Correlations between SMC4 expression and clinicopathological features of breast cancer were evaluated. The relationship between SMC4 expression and survival of patients with breast cancer was evaluated by Kaplan-Meier, GEPIA database, Cox proportional hazards regression model. Results: Bioinformatics analysis showed that the mRNA level of SMC4 in breast cancer tissues was significantly higher than that in normal adjacent tissues (P < 0.01), and was closely related to clinical stage, lymph node metastasis and chemotherapy resistance (all P < 0.05). IHC staining showed that the positive and strong positive rates of SMC4 in breast cancer tissues were significantly higher than those in normal adjacent tissues (all P < 0.05). The high protein expression of SMC4 was closely related to the age, clinical stage and lymph node metastasis of breast cancer patients (all P < 0.05). The cumulative survival rate of patients in SMC4 low expression group was significantly higher than that in the SMC4 high expression group, especially in patients with HER2+ breast cancer (P < 0.05). Additionally, SMC4 is an independent risk factor for prognosis in patients with breast cancer. Conclusion: SMC4 is highly expressed in breast cancer tissues. High SMC4 expression is closely related to lymph node metastasis, clinical stage, and prognosis of patients with breast cancer, making it a potential marker for the diagnosis and prognosis of breast cancer.
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