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“Hot-cold switch” in tumor microenvironment: Tesla Cell
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Abstract:
[Abstract] Immunotherapy has provided new approaches for tumor treatment. The immune status within the tumor microenvironment of cancer patients, characterized as‘ cold’ or‘ hot’, determines whether they will respond to immunotherapy. This article innovatively proposes the concept of‘ cell batteries (or Tesla Cell)’ to promote the‘ cold-hot switch’ of the tumor microenvironment. It reviews the current research status and progress in tumor immunotherapy, focusing on the concepts of "cold tumors" and "hot tumors, " the conversion strategies between them, as well as the types and applications of "Tesla cell"， aiming to provide a theoretical foundation for the development of new immunotherapeutic strategies for tumors.
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