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Role of acetylation modification in the occurrence and development of thyroid cancer and its potential clinical application value
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Abstract:
[Abstract] Thyroid cancer is the most prevalent malignant tumor of the endocrine system, and its incidence has shown a significant upward trend in recent years. Acetylation, an important post-translational protein modification, is involved in regulating gene transcription, cell cycle progression, and invasion ability in various types of thyroid cancers. Additionally, histone deacetylase (HDAC) inhibitors have shown potential in the treatment of thyroid cancer. This article systematically reviews the biological functions and regulatory mechanisms of acetylation in the development and progression of thyroid cancer based on recent literature. Furthermore, it discusses the clinical application prospects of HDAC inhibitors, providing a solid theoretical basis and feasible therapeutic strategies for targeted therapy of thyroid cancer.
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