目的：探讨自体CIK细胞联合放化疗治疗中晚期子宫颈癌的临床疗效。方法： 2010年10月至2015年7月开封市中心医院肿瘤诊疗中心住院的89例中晚期子宫颈癌患者，按照随机对照法以1∶1分为治疗组（44例，CIK细胞联合放化疗）和对照组（45例，单纯放化疗），比较分析两组患者治疗的有效率、生存期、免疫功能及生活质量。结果： 治疗组总有效率明显高于对照组（88.64% vs 6889%, P＜0.05)。治疗组1、2、3年生存率分别为93.18%、77.27%、47.73%，高于对照组的8888%、6889%、42.22%，但差异不显著(P>0.05)。与治疗前相比，治疗组治疗后外周血中CD3+、CD4+/CD8+显著上升(P<005)，对照组患者治疗后外周血中CD3+、CD4+/CD8+显著下降(P<0.05)。治疗组治疗25 d（T25）和治疗前1 d(B1)比较仅情感一项有显著差异（t=2.0976,P<0.05），而对照组T25与B1比较在躯体、角色、社会、整体健康有显著差异（t=33463、3.4080、2.3402、33010，P<0.05或P<0.01）；两组间T25时躯体、社会、整体健康比较有显著差异（t=2.8262、25797、19923，P<0.05或P<0.01）。结论：CIK细胞联合放化疗治疗中晚期子宫颈癌患者比单纯放化疗近期疗效好，能够明显提高患者免疫功能、改善生活质量，但尚未看到生存时间延长的获益。

Objective:To explore clinical efficacy of autologous CIK cell combined radiotherapy and chemotherapy for intermediate-advanced cervical cancer. Methods: In the randomized and controlled trial, 89 patients with intermediated-advanced cervical cancer, who were hospitalized in the center of tumor Diagnosis and Treatment, Kaifeng Center Hospital during October 2010 to July 2015, were divided into treatment group (44 cases for CIK cell combined radiatherapy and chemotherapy) and control group (45 cases for radiatherapy and chemotherapy alone) acording to ratio of 1∶1. Effective rates, survival periods, immunofunctions and qualities of life of the patients in the two groups were compared and analyzed. Results: Total effective rate of the patients in the treatment group was 88.64%, which was obviously higher than 68.89% in the control group (P<0.05). Survival rates for 1, 2 and 3 years in the treatment group were 93.18%, 72.27% and 4773% respectively, which were higher than 88.88%, 68.89% and 42.22% in the control group, but the differences were not statistically significant (P>0.05). Comparing with pre-treatment, peripheral blood CD3+ and CD4+/CD8+ of the patients in the treatment group at post-treatment significantly increased (P<0.05), and peripheral blood CD3+ and CD4+/CD8+ of the patients in the contol group at post-treatment significantly decreased (P<0.05). In the treatment group, as comparing post-treatment 25th day (T25) with pre-treatment 1st day (B1) only one item feeling had significant difference (t=2.0976, P<0.05), however in the contol group as comparing T25 with B1, body, role, social and holistic health had obvious differences (t=3.3463, 3.4080, 2.3402 and 3.3010. P<0.05 and 001). Comparison between the two groups at T25, body, social and holistic health had significant differences (t=28262, 2.5797 and 19923, P<0.05 and 0.01). Conclusion: Short-term efficacy of CIK cell combined radiotherapy and chemotherapy for the patients with intermediate-advanced cervical cancer might be better than that of radiotherapy and chemotherapy alone, which could obviously enhance immunofunction and improve life quality of the patients, but the benefit of prolonging the survival period of the patients has not yet been seen.

开封市科技攻关计划项目（No.130324）